Medline: 8380296

The abstract Journal of Clinical Oncology 11(1): 96-99, 1993. is available online.

The fulltext Journal of Clinical Oncology 11(1): 96-99, 1993. may be available online for subscribers.

Cisplatin, vincristine, and fluorouracil therapy for hepatoblastoma: a Pediatric Oncology Group study.

Douglass EC, Reynolds M, Finegold M, et al.

Abstract:

Purpose:
To estimate the disease-free survival rate in children with grossly resected hepatoblastoma treated with cisplatin, vincristine, and fluorouracil (CDDP/VCR/FU) and to assess the disease-response rate and disease-free survival (DFS) rate in children with unresectable or metastatic tumors treated with this combination.

Patients and Methods:
Sixty assessable patients with hepatoblastoma received therapy with five (Stage I and II) to seven (Stage III and IV) courses of CDDP (90 mg/m2), day 1, and VCR (1.5 mg/m2), and FU (600 mg/m2), day 3.

Results:
Nineteen of 21 patients with Stage I or II disease survive free of disease (actuarial survival, 90% at 5 years). Twenty-four of 31 patients with Stage III disease achieved a complete remission (CR) after chemotherapy and surgical excision; actuarial DFS at 4 years is 67%. Only one of eight patients with Stage IV disease achieved a remission and survives.

Conclusion:
Relatively brief exposure to chemotherapy with CDDP/VCR/FU provided excellent disease control to patients with grossly resected tumors. In patients with initially unresectable disease, this therapy provides a response rate and DFS rate comparable to regimens that contain doxorubicin (DOX).


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