Journal of Clinical Oncology 14(3): 814-820, 1996. is available online.
Journal of Clinical Oncology 14(3): 814-820, 1996. may be available online for subscribers.
Giaccone G, Ardizzoni A, Kirkpatrick A, et al.
Thymomas are rare neoplasms of the mediastinum. The role of chemotherapy in advanced thymomas is not fully established.
Patients and Methods:
In the European Organization for Research and Treatment of Cancer (EORTC) Lung Cancer Cooperative Group, 16 patients with recurrent or metastatic malignant thymoma were entered over 6 years onto a study of combination chemotherapy that consisted of cisplatin 60 mg/m2 on day 1 and etoposide 120 mg/m2 on days 1, 2, and 3, every 3 weeks.
A median of six courses per patient was administered. Main side effects of treatment were leukopenia, nausea and vomiting, and alopecia. Five complete responses and four partial responses were obtained, with a median response duration of 3.4 years. The median progression-free survival and survival times were 2.2 years and 4.3 years, respectively, with a median follow-up duration of 7 years.
The combination of cisplatin and etoposide is highly effective and well tolerated in advanced thymoma. The investigation of this combination in a neoadjuvant setting in unresectable invasive thymoma is warranted.
Rheinische Friedrich- Wilhelms- Universität Bonn