depth of coverage

Pronunciation:(... KUH-veh-rij)

Definition: Refers to the number of times a nucleotide is read during sequencing. A greater depth of coverage can increase confidence in the final results. Deep coverage aids in differentiating sequencing errors from single nucleotide polymorphisms. This can be specifically useful when a patient has a mosaicism or when a tumor is heterogeneous for a mutation.GeneticsHealth professional

2016-02-08